D-45
Cognition, Behavior, and Memory
Astrocyte-neuron interactions in long-term memory persistence
Jooyoung Kim1,2, Hayoung Kim2, Jiwoon Lim2, Erva Ozkan2, Gyu Hyun Kim3, HyoJin Park2, Mingu Gordon Park2, Bitna Joo2, Sangkyu Lee2, Kea Joo Lee3, Bong-Kiun Kaang2, C. Justin Lee2, Wuhyun Koh2
1. Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
2. Center for Memory and Glioscience, Institute for Basic Science, Daejeon, Republic of Korea.
3. Neural circuits Research Group, Korea Brain Research Institute, Daegu, Republic of Korea.
Presenting Author:
jooyoung.kim@unil.ch
Memory persistence is an important property of long-term memory. Recent studies have highlighted the contribution of astrocytes to memory processing, yet how astrocyte-neuron interactions support memory persistence remains unclear. Here, we investigated astrocytic mechanisms associated with long-term memory maintenance, including structural interactions between astrocytes and neurons. Manipulation of astrocytic Ank2 impaired remote memory without affecting recent memory and was accompanied by reduced astrocyte-neuron contacts and altered astrocyte morphology. Together, these findings suggest that astrocytic structural regulation contributes to long-term memory persistence.
